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Tirzepatide is composed of 39 amino acids, is amidated at the C-terminal, conjugates a C20 fatty diacid moiety via a spacer connected to Lys 20 , and has a half-life of 116.7 h

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However, persistent gastrointestinal side effects, pancreatitis history, or medullary thyroid cancer family history warrant provider reassessment and possible alternative approaches